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TAA Thresholds: Downward Trend Continues for 2018-2019

Client Alert | less than 1 min read | 12.13.17

On December 11, 2017, the U.S. Trade Representative published its biennial readjustment of U.S. dollar thresholds for government procurements covered by the Trade Agreements Act. The new thresholds, which go into effect January 1, 2018 for calendar years 2018 and 2019, reflect a continued decline in threshold values since the 2014-2015 revision, coinciding with the stronger value of the U.S. dollar relative to the other currencies included in market basket of currencies constituting the IMF’s Special Drawing Rights (SDRs) used to establish the thresholds contained in the WTO’s Agreement on Government Procurement.

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Client Alert | 9 min read | 10.21.26

Artificial Intelligence in Life Sciences: Reliability of AI-Generated Evidence in Drug Discovery and Development

The life sciences sector is uniquely vulnerable to the inherent risks of AI-generated evidence in drug development and discovery. This client alert focuses on five core challenges: hallucinations, skewed predictions from unrepresentative training data, the opacity of AI reasoning, input sensitivity that undermines reproducibility, and adversarial manipulation of training data. To address these risks, companies should use experimental validation and human oversight as the common legal and regulatory safety net. This entails among other measures auditing AI outputs, characterizing training data, and structural oversight. Companies also should prepare for evolving frameworks and guidance from the U.S. Food and Drug Administration (FDA) and the European Union (EU) that address use of AI in drug discovery and development .  ...